Title:	Innate Immunity as an Executor of the Programmed Death of Individual Organisms for the Benefit of the Entire Population
Authors:	Chernyak, Boris V. Lyamzaev, Konstantin G. Mulkidjanian, Armen Y.
ORCID of the author:	https://orcid.org/0000-0001-9921-8031 https://orcid.org/0000-0001-5844-3064 https://orcid.org/0000-0001-9921-8031
Abstract:	In humans, over-activation of innate immunity in response to viral or bacterial infections often causes severe illness and death. Furthermore, similar mechanisms related to innate immunity can cause pathogenesis and death in sepsis, massive trauma (including surgery and burns), ischemia/reperfusion, some toxic lesions, and viral infections including COVID-19. Based on the reviewed observations, we suggest that such severe outcomes may be manifestations of a controlled suicidal strategy protecting the entire population from the spread of pathogens and from dangerous pathologies rather than an aberrant hyperstimulation of defense responses. We argue that innate immunity may be involved in the implementation of an altruistic programmed death of an organism aimed at increasing the well-being of the whole community. We discuss possible ways to suppress this atavistic program by interfering with innate immunity and suggest that combating this program should be a major goal of future medicine.
Citations:	Chernyak B.V., Lyamzaev K.G., Mulkidjanian A.Y.: Innate Immunity as an Executor of the Programmed Death of Individual Organisms for the Benefit of the Entire Population. International Journal of Molecular Sciences. 2021; 22(24):13480.
URL:	https://doi.org/10.48693/236 https://osnadocs.ub.uni-osnabrueck.de/handle/ds-202301278110
Subject Keywords:	pathogen-associated molecular patterns (PAMPs); damage-associated molecular patterns (DAMPs); mitochondrially-targeted antioxidants; inflammation; inflammasome; programmed death; phenoptosis; COVID-19
Issue Date:	15-Dec-2021
License name:	Attribution 4.0 International
License url:	http://creativecommons.org/licenses/by/4.0/
Type of publication:	Einzelbeitrag in einer wissenschaftlichen Zeitschrift [Article]
Appears in Collections:	FB06 - Hochschulschriften Open-Access-Publikationsfonds

This item is licensed under a Creative Commons License