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The spontaneous and stimulus evoked neural dynamics of the superior colliculus in the anesthetized ferret

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https://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2014110512920
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dc.contributor.advisorProf. Dr. Andreas Karl Engel
dc.creatorStitt, Iain
dc.date.accessioned2014-11-05T14:31:53Z
dc.date.available2014-11-05T14:31:53Z
dc.date.issued2014-11-05T14:31:53Z
dc.identifier.urihttps://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2014110512920-
dc.description.abstractThe study of brain dynamics has traditionally focused study on well-established cortico-cortical, thalamo-cortical, and hippocampo-cortical pathways in the brain, neglecting other brain structures. The superior colliculus (SC) is a highly conserved midbrain structure that displays vast intrinsic, local and global patterns of anatomical connectivity, and therefore presents itself as an interesting alternative structure to study the fundamental principles of neural dynamics. Here, we report for the first time the analysis of both stimulus evoked and spontaneously generated SC neural dynamics across three spatial scales: dynamics intrinsic to the SC, local dynamical interaction with the neighboring inferior colliculus (IC), and large-scale dynamical interaction with the cortex. Within the SC, visual evoked neural dynamics was best characterized by the presence of temporally precise gamma oscillations in retinorecipient superficial SC layers following flash and grating stimuli. Local interareal dynamics in the midbrain were defined by the presence of subthreshold visually evoked activity in the IC that was driven by visual inputs from the SC. Finally, spontaneously generated SC activity is strongly governed by the state of cortical networks, with SC activity locked to prominent slow cortical and spindle oscillations. Collectively, this work provides evidence that nature of neural activity in the SC is strongly governed by both bottom-up sensory and top-down cortical inputs.eng
dc.rightsNamensnennung-Keine Bearbeitung 3.0 Unported-
dc.rights.urihttp://creativecommons.org/licenses/by-nd/3.0/-
dc.subjectferreteng
dc.subjectsuperior colliculuseng
dc.subject.ddc150 - Psychologie
dc.titleThe spontaneous and stimulus evoked neural dynamics of the superior colliculus in the anesthetized ferreteng
dc.typeDissertation oder Habilitation [doctoralThesis]-
thesis.locationOsnabrück-
thesis.institutionUniversität-
thesis.typeDissertation [thesis.doctoral]-
thesis.date2014-07-04-
dc.contributor.refereeProf. Dr. Peter König
dc.contributor.refereeProf. Dr. Gordon Pipa
vCard.ORGFB8
Enthalten in den Sammlungen:FB08 - E-Dissertationen

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